Diabetes-related foot disease-associated lower extremity amputation (LEA) is associated with substantial mortality. This raises a more relevant question: “Can reducing lower extremity amputations decrease mortality associated with diabetic foot ulcers (DFU)?.” The findings from the study by Chen et al. highlighted cardiovascular disease accounts for nearly half (46.6%; 95% CI 33.5%–59.7%) of the total deaths in individuals with DFD-related LEA and an adjusted pooled hazard ratio of post-amputation mortality rates of 2.415 (95% CI 1.323–4.408), suggesting amputations as an independent factor for mortality. The findings are substantiated from observational studies carried out in individuals with post-traumatic LEA. Hrubec et al. reported that veterans with proximal amputation had a higher risk for all-cause (RR, 1.29; 90% CI 1.18–1.41; p < 0.001) and cardiovascular (CV) mortality (RR, 1.44; 90% CI 1.26–1.64; p < 0.001). A part of the increased CV mortality is attributed to the hemodynamic changes that occur after an LEA, leading to
Dieser Beitrag wurde original veröffentlicht auf: link zum Beitrag
