KYOTO, Japan, April 22, 2025 /PRNewswire/ — A new study has found that 10-hydroxy-cis-12-octadecenoic acid (HYA), a metabolite derived from linoleic acid by gut microbiota, can help reduce postprandial hyperglycemia (high blood sugar after meals) in type 1 diabetes (T1DM) model rats. Conducted by researchers from Wakayama Medical University, Hokkaido University, and Noster Inc., this study provides new insights into how microbial metabolites can be leveraged to improve postprandial hyperglycemia.
Background on HYA and Diabetes Management
Diabetes, particularly T1DM, requires careful management of blood sugar levels to prevent complications such as cardiovascular disease, nerve damage, and vision impairment. While insulin therapy is the cornerstone of T1DM treatment, postprandial hyperglycemia remains a challenge, increasing the risk of long-term health issues.
Previous research has shown that fatty acids can influence glucose metabolism through gut hormone signaling. Linoleic acid, a common dietary fat, has been found to activate G protein-coupled receptor 120 (GPR120), promoting the secretion
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