Abstract Introduction and purpose
Type 2 diabetes is a health problem involving insulin resistance and beta cell dysfunction. Physical activity can enhance insulin sensitivity and protect beta cell function. The present study investigates the effect of 6 weeks of continuous training and high-intensity interval training on serum Growth Differentiation Factor 11 (GDF11) levels and pancreatic functions of STZ-induced diabetic rats.
Methods
Forty male Wistar rats (200-250 g) were fed a high-fat diet for 4 weeks and given intraperitoneal 30 mg/kg STZ injections. They were divided into four groups, each with 10 rats: non-diabetes, diabetes, diabetic + high-intensity intermittent training (HIIT), and diabetes + continuous training (CT). CT exercised at 15 m/min while HIIT was trained at 26 m/min, both 6 days a week over 6 weeks. Measurements included body weight, food and water intake, fasting blood glucose and insulin, GDF11, hemoglobin A1c, and pancreatic function indices.
Results
In diabetic rats, body weight, beta cell function, and insulin
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