Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes

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20.12.2024 | Article

verfasst von: Kristen J. Nadeau, Silva A. Arslanian, Fida Bacha, Sonia Caprio, Lily C. Chao, Ryan Farrell, Kara S. Hughan, Maria Rayas, Melinda Tung, Kaitlyn Cross, Laure El ghormli, on behalf of the TODAY Study Group

Erschienen in: Diabetologia

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Insulin resistance and compensatory hyperinsulinaemia are core features leading to beta cell failure in youth-onset type 2 diabetes. Insulin clearance (IC) is also a key regulator of insulin concentrations, but few data exist on IC in youth-onset type 2 diabetes. In a secondary analysis of our Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) randomised clinical trial, we investigated potential sex-, race-, ethnicity- and treatment-related differences in IC in youth-onset type 2 diabetes and aimed to identify metabolic phenotypes associated with IC at baseline and in response to

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